PHCbi LiCellMo Live Cell Metabolic Analyzer
Item#: LiCellMoVisualize real-time changes in cell metabolism without sampling...
Cells are constantly growing and differentiating, and these processes are closely linked to metabolism. In cancer immunology, stem cell research, and the development of manufacturing processes for cell-based formulations, understanding the metabolic state of cells is increasingly important for analyzing cell activation and disease.
LiCellMo offers uninterrupted, real-time insights into glucose and lactate metabolism, providing minute-by-minute data on metabolic pathways. This ground-breaking technology continuously monitors metabolites in culture, eliminating traditional, labor-intensive methods, helping open new doors to unprecedented discoveries in cell metabolism. From cancer and immunology research to stem cell studies, LiCellMo's capabilities extend to various fields, including work with organoids and cancer and stem cell research.
Product summary:
- Items monitored: Glucose, lactate (simultaneous continuous measurement of both items)
- Main device components: Controller, Detector, Plate adapter (optional product)
- Main consumables: Sensor module (single use)
- Compatible plates: 24-well plate (Compatible with 5 commercial products)
- Monitoring duration: Maximum 10 days
- Measurement range:
- Glucose: 1 to 27 mM (0.18 to 4.86 g/L)
- Lactate: 1.5 to 15 mM (0.14 to 1.35 g/L)
Controller:
- External dimensions: Width 371 mm × Depth 200 mm × Height 295 mm
- Weight: 2.5 kg (excluding accessories)
- Screen: 15.6-inch-wide touch panel display
- Extendibility: Wired connectivity for up to 4 detectors
Detector:
- External dimensions: Width 162 mm × Depth 290 mm × Height 118 mm
- Weight: 4.7 kg
- Installation: Inside CO2 incubator
- Number of units installable in PHCbi CO2 incubators*
- MCO-50 series: Max. 1 unit
- MCO-170 series, MCO-171AICUVD, MCO-230 series: Max. 4 units 92 units x 2 tiers)
*Specifications, ratings and design are subject to change without notice.
In-line sensors: the key to continuous measurements of glucose and lactate
The glycolytic pathway is one of the main components of cellular energy metabolism. During glycolysis, glucose is metabolized and lactate is produced. Conventional analysis of cell metabolism typically involves estimating glucose and lactate concentrations from data points obtained from periodic sampling. The high-precision in-line sensors of LiCellMo offer these unique advantages:
- Real-time monitoring of glucose and lactate concentrations
- Continuous measurements without sampling
- Preservation of cells for further evaluation after measurement
- Comprehensive, quantifiable data
Measure cells in their usual culture environment
The simplicity of LiCellMo's design makes it suitable for any laboratory space and does not require specialized cell culturing equipment. Common commercial products (culture medium, 24-well plates, calibration liquid, additive reagents) can be used for cell culture. The sensor module and plate adaptor can be attached to standard 24-well plates. Once the plate is placed in the detector pre-installed in the CO2 incubator, real-time, sample-free measurements can be easily monitored using the touch-panel controller. Optional plate adapters are available for five different commercial 24-well plates.
Evaluate glycolytic changes directly
LiCellMo enables direct evaluation of changes in the glycolytic pathway by measuring glucose uptake and lactate production in the cell culture medium. It visualizes cell metabolism using consumption and production rates based on concentration values, providing valuable metabolic rate data. Monitoring the efficiency of conversion from glucose to lactate makes it possible to evaluate not only glycolysis but also the balance with other cellular metabolic processes, such as the TCA cycle and oxidative phosphorylation in mitochondria.
The benefits of LiCellMo over periodic sampling methods.
- Save Time- LiCellMo does not require a researcher on-call after set up as metabolic data will be collected continuously without manual sampling.
- Capture Real-Time Metabolic Data- LiCellMo offers uninterrupted, real-time insights into glucose and lactate metabolism, providing minute-by-minute data on metabolic pathways.
- Reduce Chances of Contamination- LiCellMo helps minimize the number of times samples are handled, so the cell culture remains undisturbed during experimentation and minimizing contamination risk.
- Reduce Stress on Cells- LiCellMo allows you to keep cultures in their preferred culture environment providing optimal culturing conditions and reducing cell stress.
- Preserve Cell Samples- LiCellMo does not require addition of dyes or reagents to cell cultures, allowing researchers to preserve cells for further evaluation after measurement.
PHCbi LiCellMo™ Live Cell Metabolic Analyzer
BioTechniques In Focus: When, why and how should you continuously monitor cell metabolism?
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